Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection.
نویسندگان
چکیده
We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.
منابع مشابه
Rapid development of Candida krusei echinocandin resistance during caspofungin therapy.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 10 شماره
صفحات -
تاریخ انتشار 2008